Curphey is a surname of Manx origin. Notable people with the surname include:
- Aldington George Curphey (1880–1958), Anglo-Jamaican surgeon, medical officer and politician
- Donald Curphey (born 1948), Canadian rower
- Theodore Curphey (1897–1986), American coroner
- William Curphey (1895–1917), British World War I flying ace