Cyrus is a surname. Notable people with the surname include:
- Ron Cyrus (1935–2006), Kentucky politician, and his descendants:
- Second generation:
- Billy Ray Cyrus (born 1961), American musician and actor (son of Ron)
- Tish Cyrus (born 1967), American manager, producer and television personality (wife of Billy Ray)
- Third generation:
- Brandi Cyrus (born 1987), American actress and television personality (daughter of Billy Ray and Tish)
- Trace Cyrus (born 1989), American musician (son of Billy Ray and Tish)
- Miley Cyrus (born 1992), American actress and singer (daughter of Billy Ray and Tish)
- Noah Cyrus (born 2000), American actress and singer (daughter of Billy Ray and Tish)
- Second generation:
- Darel Cyrus (born 1996), Grenadian cricketer
- David Cyrus (born 1989), Grenadian international footballer
- Gordon Cyrus, Swedish performer and record producer
- Nauheed Cyrusi, Indian film actress