Cytochrome p450 family 19 subfamily a member 1

Cytochrome P450 family 19 subfamily A member 1 is a protein that in humans is encoded by the CYP19A1 gene.

CYP19A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Identifiers
Aliases	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
External IDs	OMIM: 107910; MGI: 88587; HomoloGene: 30955; GeneCards: CYP19A1; OMA:CYP19A1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 51,208,057 bp End 51,338,601 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A5.3|9 29.49 cM Start 54,073,221 bp End 54,175,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta right testis left testis testicle tibial nerve gonad germinal epithelium subcutaneous adipose tissue right ovary left coronary artery Top expressed in spermatocyte secondary oocyte zygote primary oocyte cumulus cell ovarian follicle cell spermatid meninges testicle seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding metal ion binding monooxygenase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen electron transfer activity oxidoreductase activity aromatase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid hydroxylase activity Cellular component endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of membrane Biological process estrogen biosynthetic process androgen metabolic process negative regulation of chronic inflammatory response prostate gland growth sterol metabolic process negative regulation of macrophage chemotaxis steroid biosynthetic process female gonad development female genitalia development mammary gland development uterus development testosterone biosynthetic process androgen catabolic process positive regulation of estradiol secretion electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1588 13075 Ensembl ENSG00000137869 ENSMUSG00000032274 UniProt P11511 P28649 RefSeq (mRNA) NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226 NM_007810 NM_001348171 NM_001348172 NM_001348173 RefSeq (protein) NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503 NP_001335100 NP_001335101 NP_001335102 NP_031836 Location (UCSC) Chr 15: 51.21 – 51.34 Mb Chr 9: 54.07 – 54.18 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

Further reading

• Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP (November 2000). "A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory". Clin. Genet. 58 (5): 375–85. doi:10.1034/j.1399-0004.2000.580508.x. PMID 11140838. S2CID 14733771.
• Baxter SW, Choong DY, Eccles DM, Campbell IG (February 2001). "Polymorphic variation in CYP19 and the risk of breast cancer". Carcinogenesis. 22 (2): 347–9. doi:10.1093/carcin/22.2.347. PMID 11181459.
• Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev MY, Sokolov EP, Togo A, Hanson KP, Poroshina TE, Vasiljev DA, Kovalevskij AY, Gamajunova VB (February 2001). "CYP19 gene polymorphism in endometrial cancer patients". J. Cancer Res. Clin. Oncol. 127 (2): 135–8. doi:10.1007/s004320000200. PMID 11216915. S2CID 31884230.
• Tucci S, Futterweit W, Concepcion ES, Greenberg DA, Villanueva R, Davies TF, Tomer Y (January 2001). "Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus". J. Clin. Endocrinol. Metab. 86 (1): 446–9. doi:10.1210/jcem.86.1.7274. PMID 11232039.
• Masi L, Becherini L, Gennari L, Amedei A, Colli E, Falchetti A, Farci M, Silvestri S, Gonnelli S, Brandi ML (May 2001). "Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk". J. Clin. Endocrinol. Metab. 86 (5): 2263–9. doi:10.1210/jcem.86.5.7450. PMID 11344237.
• Latil AG, Azzouzi R, Cancel GS, Guillaume EC, Cochan-Priollet B, Berthon PL, Cussenot O (September 2001). "Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways". Cancer. 92 (5): 1130–7. doi:10.1002/1097-0142(20010901)92:5<1130::aid-cncr1430>3.0.co;2-b. PMID 11571725.
• Modugno F, Weissfeld JL, Trump DL, Zmuda JM, Shea P, Cauley JA, Ferrell RE (October 2001). "Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk". Clin. Cancer Res. 7 (10): 3092–6. PMID 11595700.
• Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S (December 2001). "Role of aromatase in endometrial disease". J. Steroid Biochem. Mol. Biol. 79 (1–5): 19–25. doi:10.1016/s0960-0760(01)00134-0. PMID 11850203. S2CID 7642211.
• Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, Kao YC, Itoh T (December 2001). "Modulation of aromatase expression in human breast tissue". J. Steroid Biochem. Mol. Biol. 79 (1–5): 35–40. doi:10.1016/s0960-0760(01)00132-7. PMID 11850205. S2CID 33879090.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.