Cytoskeleton regulator RNA

Cytoskeleton regulator RNA is a long non-coding RNA that in humans is encoded by the CYTOR gene.

CYTOR
Identifiers
Aliases	CYTOR, C2orf59, NCRNA00152, LINC00152, long intergenic non-protein coding RNA 152, cytoskeleton regulator RNA
External IDs	GeneCards: CYTOR; OMA:CYTOR - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p11.2 Start 87,454,781 bp End 87,636,740 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells monocyte granulocyte spleen blood epithelium of colon subcutaneous adipose tissue lymph node islet of Langerhans stromal cell of endometrium n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 112597 n/a Ensembl ENSG00000222041 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 2: 87.45 – 87.64 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

CYTOR plays a role in breast cancer. It regulates genes involved in the EGFR/mammalian target of rapamycin pathway and is required for cell proliferation, cell migration, and cytoskeleton organization.

Further reading

• Van Grembergen O, Bizet M, de Bony EJ, Calonne E, Putmans P, Brohée S, Olsen C, Guo M, Bontempi G, Sotiriou C, Defrance M, Fuks F (2016). "Portraying breast cancers with long noncoding RNAs". Sci Adv. 2 (9): e1600220. Bibcode:2016SciA....2E0220V. doi:10.1126/sciadv.1600220. PMC 5010371. PMID 27617288.
• Pang Q, Ge J, Shao Y, Sun W, Song H, Xia T, Xiao B, Guo J (2014). "Increased expression of long intergenic non-coding RNA LINC00152 in gastric cancer and its clinical significance". Tumour Biol. 35 (6): 5441–7. doi:10.1007/s13277-014-1709-3. PMID 24523021. S2CID 1025668.
• Tani H, Onuma Y, Ito Y, Torimura M (2014). "Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells". PLOS ONE. 9 (8): e106282. Bibcode:2014PLoSO...9j6282T. doi:10.1371/journal.pone.0106282. PMC 4149554. PMID 25171338.
• Zhao J, Liu Y, Zhang W, Zhou Z, Wu J, Cui P, Zhang Y, Huang G (2015). "Long non-coding RNA Linc00152 is involved in cell cycle arrest, apoptosis, epithelial to mesenchymal transition, cell migration and invasion in gastric cancer". Cell Cycle. 14 (19): 3112–23. doi:10.1080/15384101.2015.1078034. PMC 4825539. PMID 26237576.
• Li J, Wang X, Tang J, Jiang R, Zhang W, Ji J, Sun B (2015). "HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma". Cell. Physiol. Biochem. 37 (2): 687–96. doi:10.1159/000430387. PMID 26356260.
• Zhou J, Zhi X, Wang L, Wang W, Li Z, Tang J, Wang J, Zhang Q, Xu Z (2015). "Linc00152 promotes proliferation in gastric cancer through the EGFR-dependent pathway". J. Exp. Clin. Cancer Res. 34: 135. doi:10.1186/s13046-015-0250-6. PMC 4632266. PMID 26538117.
• Ji J, Tang J, Deng L, Xie Y, Jiang R, Li G, Sun B (2015). "LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway". Oncotarget. 6 (40): 42813–24. doi:10.18632/oncotarget.5970. PMC 4767473. PMID 26540343.
• Chen WM, Huang MD, Sun DP, Kong R, Xu TP, Xia R, Zhang EB, Shu YQ (2016). "Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer". Oncotarget. 7 (9): 9773–87. doi:10.18632/oncotarget.6949. PMC 4891083. PMID 26799422.
• Yue B, Cai D, Liu C, Fang C, Yan D (2016). "Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer". Mol. Ther. 24 (12): 2064–2077. doi:10.1038/mt.2016.180. PMC 5167786. PMID 27633443.
• Hu HB, Jie HY, Zheng XX (2016). "Three Circulating LncRNA Predict Early Progress of Esophageal Squamous Cell Carcinoma". Cell. Physiol. Biochem. 40 (1–2): 117–125. doi:10.1159/000452529. PMID 27855375.