Wikipedia

Cytosol nonspecific dipeptidase

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene.[5][6][7] This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor.[8] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis".[9] A similiar pathway conjugates amino acids to Beta-hydroxybutyric acid.[10]

CNDP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNDP2, CN2, CPGL, HEL-S-13, HsT2298, PEPA, CNDP dipeptidase 2 (metallopeptidase M20 family), carnosine dipeptidase 2
External IDsOMIM: 169800; MGI: 1913304; HomoloGene: 10085; GeneCards: CNDP2; OMA:CNDP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

55748

66054

Ensembl

ENSG00000133313

ENSMUSG00000024644

UniProt

Q96KP4

Q9D1A2

RefSeq (mRNA)

NM_001289531
NM_023149

RefSeq (protein)

NP_001276460
NP_075638

Location (UCSC)Chr 18: 74.5 – 74.52 MbChr 18: 84.69 – 84.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Cytosol nonspecific dipeptidase
Identifiers
EC no.3.4.13.18
CAS no.9025-31-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133313 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024644 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry. 278 (8): 6521–6531. doi:10.1074/jbc.M209764200. PMID 12473676.
  6. ^ "Entrez Gene: CNDP2 carnosine dipeptidase 2".
  7. ^ Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1520–1522.
  8. ^ "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens".
  9. ^ Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. (May 11, 2015). "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids". Proceedings of the National Academy of Sciences of the USA. 112 (21): 6601–6606. Bibcode:2015PNAS..112.6601J. doi:10.1073/pnas.1424638112. PMC 4450436. PMID 25964343.
  10. ^ Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, et al. (2024). "A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites". Cell. doi:10.1016/j.cell.2024.10.032. PMID 39536746.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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