D-arabinitol dehydrogenase (NADP+)

D-arabinitol dehydrogenase (NADP+) (EC 1.1.1.287, NADP+-dependent D-arabitol dehydrogenase, ARD1p, D-arabitol dehydrogenase 1) is an enzyme with systematic name D-arabinitol:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

D-arabinitol dehydrogenase (NADP+)
Identifiers
EC no.1.1.1.287
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins
(1) D-arabinitol + NADP+ D-xylulose + NADPH + H+
(2) D-arabinitol + NADP+ D-ribulose + NADPH + H+

The enzyme present in the fungus Uromyces fabae can make use D-arabinitol and D-mannitol in the forward direction, and D-xylulose, D-ribulose and D-fructose in the reverse direction.

References

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  1. ^ Link T, Lohaus G, Heiser I, Mendgen K, Hahn M, Voegele RT (July 2005). "Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae". The Biochemical Journal. 389 (Pt 2): 289–95. doi:10.1042/BJ20050301. PMC 1175105. PMID 15796718.
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