D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.70 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- D-glycero-beta-D-manno-heptose 1-phosphate + ATP ADP-D-glycero-beta-D-manno-heptose + diphosphate
The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.
References
edit- ^ Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD (January 2000). "The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose". Journal of Bacteriology. 182 (2): 488–97. doi:10.1128/jb.182.2.488-497.2000. PMC 94300. PMID 10629197.
- ^ Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC 139585. PMID 11751812.
- ^ Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi:10.1099/00221287-148-7-1979. PMID 12101286.
- ^ Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (February 2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49 (6): 1072–81. doi:10.1021/bi902018y. PMC 2844805. PMID 20050615.
External links
edit- D-glycero-beta-D-manno-heptose+1-phosphate+adenylyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
