D-inositol-3-phosphate glycosyltransferase

D-inositol-3-phosphate glycosyltransferase (EC 2.4.1.250, mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

D-inositol-3-phosphate glycosyltransferase
Identifiers
EC no.2.4.1.250
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP

This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.

References

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  1. ^ Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y (June 2003). "The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)". Journal of Bacteriology. 185 (11): 3476–9. doi:10.1128/JB.185.11.3476-3479.2003. PMC 155378. PMID 12754249.
  2. ^ Newton GL, Ta P, Bzymek KP, Fahey RC (November 2006). "Biochemistry of the initial steps of mycothiol biosynthesis". The Journal of Biological Chemistry. 281 (45): 33910–20. doi:10.1074/jbc.M604724200. PMID 16940050.
  3. ^ Vetting MW, Frantom PA, Blanchard JS (June 2008). "Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis". The Journal of Biological Chemistry. 283 (23): 15834–44. doi:10.1074/jbc.M801017200. PMC 2414306. PMID 18390549.
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