D-ribitol-5-phosphate cytidylyltransferase

In enzymology, a D-ribitol-5-phosphate cytidylyltransferase (EC 2.7.7.40) is an enzyme that catalyzes the chemical reaction

D-ribitol-5-phosphate cytidylyltransferase
Identifiers
EC no.2.7.7.40
CAS no.9027-07-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
CTP + D-ribitol 5-phosphate diphosphate + CDP-ribitol

Thus, the two substrates of this enzyme are CTP and D-ribitol 5-phosphate, whereas its two products are diphosphate and CDP-ribitol.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:D-ribitol-5-phosphate cytidylyltransferase. Other names in common use include CDP ribitol pyrophosphorylase, cytidine diphosphate ribitol pyrophosphorylase, ribitol 5-phosphate cytidylyltransferase, and cytidine diphosphoribitol pyrophosphorylase. This enzyme participates in pentose and glucuronate interconversions.

References

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  • Shaw DR (February 1962). "Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol". The Biochemical Journal. 82: 297–312. PMC 1243453. PMID 13911452.