D-sedoheptulose 7-phosphate isomerase (EC 5.3.1.28, sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene), lpcA (gene)) is an enzyme with systematic name D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| D-sedoheptulose 7-phosphate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.1.28 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- D-sedoheptulose 7-phosphate D-glycero-D-manno-heptose 7-phosphate
In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-β-D-manno-heptose.
References
edit- ^ Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC 139585. PMID 11751812.
- ^ Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P (June 2001). "Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose". The Journal of Biological Chemistry. 276 (24): 20935–44. doi:10.1074/jbc.m100378200. PMID 11279237.
- ^ Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi:10.1099/00221287-148-7-1979. PMID 12101286.
- ^ Kim MS, Shin DH (November 2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei". Acta Crystallographica Section F. 65 (Pt 11): 1110–2. doi:10.1107/s174430910903259x. PMC 2777036. PMID 19923728.
- ^ Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS (February 2008). "Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants". The Journal of Biological Chemistry. 283 (5): 2835–45. doi:10.1074/jbc.m706163200. PMID 18056714.
External links
edit- D-sedoheptulose+7-phosphate+isomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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