D-sorbitol dehydrogenase (acceptor)

In enzymology, a D-sorbitol dehydrogenase (acceptor) (EC 1.1.99.21) is an enzyme that catalyzes the chemical reaction

D-sorbitol dehydrogenase (acceptor)
Identifiers
EC no.1.1.99.21
CAS no.9028-22-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
D-sorbitol + acceptor L-sorbose + reduced acceptor

Thus, the two substrates of this enzyme are D-sorbitol and acceptor, whereas its two products are L-sorbose and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-sorbitol:acceptor 1-oxidoreductase. This enzyme is also called D-sorbitol:(acceptor) 1-oxidoreductase. This enzyme participates in fructose and mannose metabolism. It employs one cofactor, FAD.

References

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  • Shinagawa E, Ameyama M (1982). "Purification and characterization of D-sorbitol dehydrogenase from membrane of Gluconobacter suboxydans var-alpha". Agric. Biol. Chem. 46: 135–141. doi:10.1271/bbb1961.46.135.