DAP (gene)

DAP
Identifiers
Aliases	DAP, death associated protein
External IDs	OMIM: 600954; MGI: 1918190; HomoloGene: 3235; GeneCards: DAP; OMA:DAP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	10,761,234 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	31,274,487 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; stromal cell of endometrium; ; islet of Langerhans; ; gallbladder; ; right coronary artery; ; thoracic aorta; ; ascending aorta; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex;
	Top expressed in
	transitional epithelium of urinary bladder; ; calvaria; ; gastrula; ; blood; ; pyloric antrum; ; pancreas; ; islet of Langerhans; ; left lobe of liver; ; ankle; ; body of femur;
	More reference expression data
	More reference expression data
Orthologs
	1611
	223453
	ENSG00000112977
	ENSMUSG00000039168
	P51397
	Q91XC8
	NM_004394; NM_001291963
	NM_146057
	NP_001278892; NP_004385
	NP_666169
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.^[5]^[6]^[7]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112977 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
^ Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev. 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
^ ^a ^b "Entrez Gene: DAP death-associated protein".

Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene. 17 (25): 3331–40. doi:10.1038/sj.onc.1202588. PMID 9916995.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID 16602700.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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