DCAF11

DCAF11
Identifiers
Aliases	DCAF11, PRO2389, WDR23, GL014, DDB1 and CUL4 associated factor 11
External IDs	OMIM: 613317; MGI: 90168; HomoloGene: 11886; GeneCards: DCAF11; OMA:DCAF11 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,125,242 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,807,522 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; body of pancreas; ; sural nerve; ; skeletal muscle tissue; ; blood; ; granulocyte; ; muscle of leg; ; bone marrow; ; gastrocnemius muscle;
	Top expressed in
	left lobe of liver; ; ankle; ; vestibular membrane of cochlear duct; ; right kidney; ; muscle of thigh; ; transitional epithelium of urinary bladder; ; temporal muscle; ; right ventricle; ; sternocleidomastoid muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Cul4-RING E3 ubiquitin ligase complex; nucleoplasm;
Biological process	post-translational protein modification; protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	80344
	28199
	ENSG00000100897; ENSG00000284796
	ENSMUSG00000022214
	Q8TEB1
	Q91VU6
	NM_001163484; NM_025230; NM_181357
	NM_001199009; NM_133734
	NP_001156956; NP_079506; NP_852002
	NP_001185938; NP_598495
	Wikidata
View/Edit Human	View/Edit Mouse

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.

DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.^[5] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.^[6]

References

^ ^a ^b ^c ENSG00000284796 GRCh38: Ensembl release 89: ENSG00000100897, ENSG00000284796 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022214 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.
^ Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866. This article incorporates text from this source, which is available under the CC BY 4.0 license.

Siswanto FM, Oguro A, Arase S, Imaoka S (October 2020). "WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes". Drug Metabolism and Pharmacokinetics. 35 (5): 441–455. doi:10.1016/j.dmpk.2020.06.007. PMID 32839090. S2CID 221307354.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
Le R, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, et al. (April 2021). "Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells". Cell Stem Cell. 28 (4): 732–747.e9. doi:10.1016/j.stem.2020.11.018. PMID 33357405. S2CID 229693249.
Wang K, Liu Y, Yu Z, Gu B, Hu J, Huang L, et al. (November 2021). "Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle". Cell Reports. 37 (6): 109987. doi:10.1016/j.celrep.2021.109987. PMID 34758320. S2CID 243952009.
Siswanto FM, Sakuma R, Oguro A, Imaoka S (August 2022). "Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 77 (8): 1503–1516. doi:10.1093/gerona/glac062. PMID 35279029.

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[refGRCh38Ensembl-1] ENSG00000284796 GRCh38: Ensembl release 89: ENSG00000100897, ENSG00000284796 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022214 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.

[6] Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866. This article incorporates text from this source, which is available under the CC BY 4.0 license.

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DCAF11

References

Further reading