Probable ATP-dependent RNA helicase DDX23 is an enzyme that in humans is encoded by the DDX23 gene.[5][6][7]

DDX23
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDDX23, PRPF28, SNRNP100, U5-100K, U5-100KD, prp28, DEAD-box helicase 23
External IDsOMIM: 612172; MGI: 1921601; HomoloGene: 3542; GeneCards: DDX23; OMA:DDX23 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004818

NM_001080981

RefSeq (protein)

NP_004809

n/a

Location (UCSC)Chr 12: 48.83 – 48.85 MbChr 15: 98.54 – 98.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174243Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003360Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Teigelkamp S, Mundt C, Achsel T, Will CL, Luhrmann R (Jan 1998). "The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p". RNA. 3 (11): 1313–26. PMC 1369570. PMID 9409622.
  6. ^ Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. Bibcode:1998PNAS...95.4188L. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711.
  7. ^ a b "Entrez Gene: DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23".

Further reading

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