DEFB119

Beta-defensin 119 is a protein that in humans is encoded by the DEFB119 gene.

DEFB119
Identifiers
Aliases	DEFB119, DEFB-19, DEFB-20, DEFB120, ESC42-RELA, ESC42-RELB, DEFB20, defensin beta 119
External IDs	OMIM: 615997; MGI: 2385955; HomoloGene: 17045; GeneCards: DEFB119; OMA:DEFB119 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q11.21 Start 31,377,164 bp End 31,390,590 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H1 Start 152,418,006 bp End 152,422,232 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis right testis left testis testicle tail of epididymis buccal mucosa cell caput epididymis sperm right coronary artery retinal pigment epithelium Top expressed in Gonadal ridge seminiferous tubule spermatocyte embryo spermatid cumulus cell efferent ductule epithelium of seminiferous tubule of testis Sertoli cell morula More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding Cellular component extracellular region cell surface Biological process defense response to bacterium defense response innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245932 246700 Ensembl ENSG00000180483 ENSMUSG00000050645 UniProt Q8N690 Q8K3I8 RefSeq (mRNA) NM_001271209 NM_153289 NM_153323 NM_145157 RefSeq (protein) NP_001258138 NP_695021 NP_697018 NP_660139 Location (UCSC) Chr 20: 31.38 – 31.39 Mb Chr 2: 152.42 – 152.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Lehrer RI, Ganz T (2002). "Defensins of vertebrate animals". Curr. Opin. Immunol. 14 (1): 96–102. doi:10.1016/S0952-7915(01)00303-X. PMID 11790538.
• Raj PA, Dentino AR (2002). "Current status of defensins and their role in innate and adaptive immunity". FEMS Microbiol. Lett. 206 (1): 9–18. doi:10.1111/j.1574-6968.2002.tb10979.x. PMID 11786250.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamamoto M, Matsui Y (2003). "Testis-specific expression of a novel mouse defensin-like gene, Tdl". Mech. Dev. 116 (1–2): 217–21. doi:10.1016/S0925-4773(02)00144-2. PMID 12128228. S2CID 15160486.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.