DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae . The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3 , mouse Dj3 and rat Dj2 gene products.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000069345 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031701 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA" . Mol Cell Biol . 18 (9): 5546–56. doi :10.1128/MCB.18.9.5546 . PMC 109139 PMID 9710638 . ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature" . Cell Stress & Chaperones . 5 (2): 98–112. doi :10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-11-02). ISSN 1466-1268 . PMC 312896 PMID 11147971 . {{cite journal }}: CS1 maint: DOI inactive as of November 2024 (link )^ a b "Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2" .
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