In molecular biology, the δ (delta) subunit of DNA polymerase III is encoded by the holA gene in E. coli and other bacteria. Along with the γ, δ', χ, and ψ subunits that make up the core polymerase, and the β accessory proteins, the δ subunit is responsible for the high speed and processivity of polIII.[1][2]
| DNA polymerase III, delta subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | holA | ||||||
| Entrez | 947573 | ||||||
| RefSeq (Prot) | NP_415173.1 | ||||||
| UniProt | P28630 | ||||||
| Other data | |||||||
| EC number | 2.7.7.7 | ||||||
| Chromosome | genome: 0.67 - 0.67 Mb | ||||||
| |||||||
| DNA polymerase III, delta subunit | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 atpgs bound e. coli clamp loader complex | |||||||||
| Identifiers | |||||||||
| Symbol | DNA_pol3_delta | ||||||||
| Pfam | PF06144 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR010372 | ||||||||
| SCOP2 | 1jql / SCOPe / SUPFAM | ||||||||
| |||||||||
References
edit- ^ Dong Z, Onrust R, Skangalis M, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'" (PDF). The Journal of Biological Chemistry. 268 (16): 11758–65. doi:10.1016/S0021-9258(19)50264-2. PMID 8505303.
- ^ Carter JR, Franden MA, Aebersold R, McHenry CS (1992). "Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme". Journal of Bacteriology. 174 (21): 7013–25. doi:10.1128/jb.174.21.7013-7025.1992. PMC 207382. PMID 1400251.
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