DNM3

Dynamin-3 is a protein that in humans is encoded by the DNM3 gene. The protein encoded by this gene is a member of the dynamin family which possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding. DNM3 is upregulated in Sézary's syndrome.

DNM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L43, 5A3F
Identifiers
Aliases	DNM3, Dyna III, dynamin 3
External IDs	OMIM: 611445; MGI: 1341299; HomoloGene: 22906; GeneCards: DNM3; OMA:DNM3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.3 Start 171,817,887 bp End 172,418,466 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H2.1 Start 161,810,022 bp End 162,305,603 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pons Brodmann area 46 corpus callosum pars compacta postcentral gyrus superior vestibular nucleus dorsal motor nucleus of vagus nerve pars reticulata orbitofrontal cortex Top expressed in facial motor nucleus anterior horn of spinal cord superior colliculus central gray substance of midbrain inferior colliculi pontine nuclei medial vestibular nucleus substantia nigra dorsal tegmental nucleus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding nitric-oxide synthase binding type 1 metabotropic glutamate receptor binding GTP binding type 5 metabotropic glutamate receptor binding protein binding hydrolase activity GTPase activity microtubule binding identical protein binding structural constituent of postsynapse Cellular component cytoplasm Golgi apparatus postsynaptic density photoreceptor inner segment dendritic spine synapse axon dendritic spine head mitochondrion perinuclear region of cytoplasm synaptic cleft microtubule extracellular exosome cytoskeleton mitochondrial membranes postsynaptic endocytic zone membrane plasma membrane membrane cytoplasmic vesicle postsynaptic membrane apical tubulobulbar complex basal tubulobulbar complex presynapse glutamatergic synapse Biological process endocytosis positive regulation of filopodium assembly regulation of dendritic spine morphogenesis negative regulation of dendritic spine morphogenesis mitochondrial fission dynamin family protein polymerization involved in mitochondrial fission synapse assembly filopodium assembly membrane fusion synaptic vesicle budding from presynaptic endocytic zone membrane postsynaptic neurotransmitter receptor internalization receptor internalization synaptic vesicle endocytosis regulation of synapse structure or activity postsynapse organization positive regulation of synaptic vesicle recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26052 103967 Ensembl ENSG00000197959 ENSMUSG00000040265 UniProt Q9UQ16 Q8BZ98 RefSeq (mRNA) NM_001136127 NM_001278252 NM_015569 NM_001350204 NM_001350205 NM_001350206 NM_001038619 NM_172646 RefSeq (protein) NP_001129599 NP_001265181 NP_056384 NP_001337133 NP_001337134 NP_001337135 NP_001033708 NP_766234 Location (UCSC) Chr 1: 171.82 – 172.42 Mb Chr 1: 161.81 – 162.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Sever S (2003). "Dynamin and endocytosis". Curr. Opin. Cell Biol. 14 (4): 463–7. doi:10.1016/S0955-0674(02)00347-2. PMID 12383797.
• Wiejak J, Wyroba E (2003). "Dynamin: characteristics, mechanism of action and function". Cell. Mol. Biol. Lett. 7 (4): 1073–80. PMID 12511974.
• Orth JD, McNiven MA (2003). "Dynamin at the actin-membrane interface". Curr. Opin. Cell Biol. 15 (1): 31–9. doi:10.1016/S0955-0674(02)00010-8. PMID 12517701.
• Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
• Larsen MR, Graham ME, Robinson PJ, Roepstorff P (2004). "Improved detection of hydrophilic phosphopeptides using graphite powder microcolumns and mass spectrometry: evidence for in vivo doubly phosphorylated dynamin I and dynamin III". Mol. Cell. Proteomics. 3 (5): 456–65. doi:10.1074/mcp.M300105-MCP200. PMID 14762214.
• Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi:10.1074/jbc.M404899200. PMID 15252009.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9UQ16 (Dynamin-3) at the PDBe-KB.