DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks.[1] DOCK family members contain a RhoGEF domain to function as guanine nucleotide exchange factors to promote GDP release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive when bound to GDP but active when bound to GTP.
| Dedicator of cytokinesis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbol | Ded_cyto | ||||||||||
| Pfam | PF06920 | ||||||||||
| InterPro | IPR026791 | ||||||||||
| SCOP2 | 1wg7 / SCOPe / SUPFAM | ||||||||||
| CDD | cd11684 | ||||||||||
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Subfamilies
editDOCK family proteins are categorised into four subfamilies based on their sequence homology:
- DOCK-A subfamily
- DOCK-B subfamily
- DOCK-C subfamily (also known as Zir subfamily)
- DOCK-D subfamily (also known as Zizimin subfamily)
References
edit- ^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.
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