DOK4

DOK4
Identifiers
Aliases	DOK4, IRS-5, IRS5, docking protein 4
External IDs	OMIM: 608333; MGI: 2148865; HomoloGene: 10009; GeneCards: DOK4; OMA:DOK4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	57,487,327 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,602,958 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; tendon of biceps brachii; ; right coronary artery; ; duodenum; ; Descending thoracic aorta; ; rectum; ; ganglionic eminence; ; spinal ganglia; ; ascending aorta; ; skin of leg;
	Top expressed in
	lumbar spinal ganglion; ; interventricular septum; ; intestinal villus; ; ileum; ; lip; ; jejunum; ; genital tubercle; ; duodenum; ; barrel cortex; ; left colon;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol;
Biological process	axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	55715
	114255
	ENSG00000125170
	ENSMUSG00000040631
	Q8TEW6
	Q99KE3
	NM_018110; NM_001330556
	NM_053246
NP_001317485; NP_060580; NP_001356547; NP_001356548; NP_001356549;
	NP_001356550
	NP_444476
	Wikidata
View/Edit Human	View/Edit Mouse

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125170 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040631 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
^ "Entrez Gene: DOK4 docking protein 4".

Al-Sarraf N, Reiff JN, Hinrichsen J, et al. (2007). "DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma". Int. J. Cancer. 121 (5): 992–8. doi:10.1002/ijc.22776. PMID 17443497. S2CID 41483929.
Uchida M, Enomoto A, Fukuda T, et al. (2007). "Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase". J. Cell Sci. 119 (Pt 15): 3067–77. doi:10.1242/jcs.03043. PMID 16820412.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125170 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040631 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10493829-5] Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.

[entrez-6] "Entrez Gene: DOK4 docking protein 4".

[5]

[6]

[1]

[2]

[3]

[4]

DOK4

References

Further reading