DPP10

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

DPP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WJL
Identifiers
Aliases	DPP10, DPL2, DPPY, DPRP-3, DPRP3, dipeptidyl peptidase like 10
External IDs	OMIM: 608209; MGI: 2442409; HomoloGene: 41400; GeneCards: DPP10; OMA:DPP10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.1 Start 114,442,299 bp End 115,845,780 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E2.3 Start 123,249,200 bp End 124,773,776 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 cingulate gyrus anterior cingulate cortex primary visual cortex amygdala Top expressed in substantia nigra piriform cortex prefrontal cortex temporal lobe amygdala primary motor cortex cingulate gyrus lateral septal nucleus lobe of cerebellum medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel regulator activity serine-type peptidase activity dipeptidyl-peptidase activity transmembrane transporter binding Cellular component integral component of membrane plasma membrane membrane voltage-gated potassium channel complex Biological process protein localization to plasma membrane regulation of potassium ion transmembrane transport proteolysis positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57628 269109 Ensembl ENSG00000175497 ENSMUSG00000036815 UniProt Q8N608 Q6NXK7 RefSeq (mRNA) NM_001004360 NM_001178034 NM_001178036 NM_001178037 NM_020868 NM_001321905 NM_001321906 NM_001321907 NM_001321908 NM_001321909 NM_001321910 NM_001321911 NM_001321912 NM_001321913 NM_001321914 NM_001399849 NM_001399850 NM_001399851 NM_199021 RefSeq (protein) NP_001004360 NP_001171505 NP_001171507 NP_001171508 NP_001308834 NP_001308835 NP_001308836 NP_001308837 NP_001308838 NP_001308839 NP_001308840 NP_001308841 NP_001308842 NP_001308843 NP_065919 NP_950186 NP_001393353 NP_001393354 NP_001393355 Location (UCSC) Chr 2: 114.44 – 115.85 Mb Chr 1: 123.25 – 124.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.

Clinical significance

Mutations in this gene have been associated with asthma and autism spectrum disorders.

Further reading

• Yamada R, Ymamoto K (2005). "Recent findings on genes associated with inflammatory disease". Mutat. Res. 573 (1–2): 136–51. doi:10.1016/j.mrfmmm.2004.06.061. PMID 15829243.
• Chen T, Ajami K, McCaughan GW, Gorrell MD, Abbott CA (2003). "Dipeptidyl Peptidase IV Gene Family". Dipeptidyl peptidase IV gene family. The DPIV family. Adv. Exp. Med. Biol. Vol. 524. Springer. pp. 79–86. doi:10.1007/0-306-47920-6_10. ISBN 9780306479205. PMID 12675227.
• Allen M, Heinzmann A, Noguchi E, Abecasis G, Broxholme J, Ponting CP, Bhattacharyya S, Tinsley J, Zhang Y, Holt R, Jones EY, Lench N, Carey A, Jones H, Dickens NJ, Dimon C, Nicholls R, Baker C, Xue L, Townsend E, Kabesch M, Weiland SK, Carr D, von Mutius E, Adcock IM, Barnes PJ, Lathrop GM, Edwards M, Moffatt MF, Cookson WO (November 2003). "Positional cloning of a novel gene influencing asthma from chromosome 2q14". Nat. Genet. 35 (3): 258–63. doi:10.1038/ng1256. PMID 14566338. S2CID 40595323.
• Jerng HH, Qian Y, Pfaffinger PJ (2005). "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)". Biophys. J. 87 (4): 2380–96. doi:10.1529/biophysj.104.042358. PMC 1304660. PMID 15454437.
• Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, McCormack T, Akinsanya KO, Qi SY, Rudy B (May 2005). "DPP10 modulates Kv4-mediated A-type potassium channels". J. Biol. Chem. 280 (19): 18853–61. doi:10.1074/jbc.M410613200. PMID 15671030.
• Ren X, Hayashi Y, Yoshimura N, Takimoto K (2005). "Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels". Mol. Cell. Neurosci. 29 (2): 320–32. doi:10.1016/j.mcn.2005.02.003. PMID 15911355. S2CID 34065803.
• Chen T, Ajami K, McCaughan GW, Gai WP, Gorrell MD, Abbott CA (January 2006). "Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity". Biochim. Biophys. Acta. 1764 (1): 33–43. doi:10.1016/j.bbapap.2005.09.013. PMID 16290253.
• Takimoto K, Hayashi Y, Ren X, Yoshimura N (2006). "Species and tissue differences in the expression of DPPY splicing variants". Biochem. Biophys. Res. Commun. 348 (3): 1094–100. doi:10.1016/j.bbrc.2006.07.157. PMID 16899223.
• Jerng HH, Lauver AD, Pfaffinger PJ (2007). "DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels". Mol. Cell. Neurosci. 35 (4): 604–24. doi:10.1016/j.mcn.2007.03.008. PMC 3674967. PMID 17475505.
• Hersh CP, Raby BA, Soto-Quirós ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST, Celedón JC (November 2007). "Comprehensive testing of positionally cloned asthma genes in two populations". Am. J. Respir. Crit. Care Med. 176 (9): 849–57. doi:10.1164/rccm.200704-592OC. PMC 2048676. PMID 17702965.