The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Schenker T, Trueb B (Jun 1998). "Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 274–5. doi:10.1159/000134741. PMID9605870.
Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1–3): 196–204. doi:10.1016/s0167-4781(00)00025-7. PMID10760581.
Vlangos CN, Das P, Patel PI, Elsea SH (2000). "Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval". Cytogenet. Cell Genet. 88 (3–4): 283–5. doi:10.1159/000015539. PMID10828610. S2CID32462696.
Song H, Kim SI, Ko MS, et al. (2005). "Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis". J. Biochem. 135 (3): 331–5. doi:10.1093/jb/mvh040. PMID15113831.
