DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (EC 2.1.1.235, TylM1) is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.235 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-glucopyranose
The enzyme is involved in the biosynthesis of mycaminose.
References
edit- ^ Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW (July 2002). "Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine". Biochemistry. 41 (29): 9165–83. doi:10.1021/bi020245j. PMID 12119032.
- ^ Carney AE, Holden HM (February 2011). "Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose". Biochemistry. 50 (5): 780–7. doi:10.1021/bi101733y. PMC 3079244. PMID 21142177.
External links
edit- DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose+N,N-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
