DTX1

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.

DTX1
Identifiers
Aliases	DTX1, hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
External IDs	OMIM: 602582; MGI: 1352744; HomoloGene: 74522; GeneCards: DTX1; OMA:DTX1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.13 Start 113,056,730 bp End 113,098,028 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 60.64 cM Start 120,818,267 bp End 120,849,992 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right frontal lobe cingulate gyrus anterior cingulate cortex right hemisphere of cerebellum nucleus accumbens Brodmann area 9 amygdala ganglionic eminence prefrontal cortex Top expressed in entorhinal cortex mesenteric lymph nodes perirhinal cortex dentate gyrus of hippocampal formation granule cell primary visual cortex motor neuron superior colliculus cerebellar cortex lumbar subsegment of spinal cord Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding transcription coactivator activity zinc ion binding protein binding ubiquitin protein ligase binding metal ion binding Notch binding transferase activity Cellular component cytoplasm nucleus nucleoplasm cytosol nuclear body Biological process Notch signaling pathway cell surface receptor signaling pathway glial cell differentiation transcription by RNA polymerase II regulation of Notch signaling pathway negative regulation of T cell differentiation negative regulation of neuron differentiation protein ubiquitination transcription, DNA-templated cellular response to leukemia inhibitory factor positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1840 14357 Ensembl ENSG00000135144 ENSMUSG00000029603 UniProt Q86Y01 Q61010 RefSeq (mRNA) NM_004416 NM_008052 RefSeq (protein) NP_004407 NP_032078 Location (UCSC) Chr 12: 113.06 – 113.1 Mb Chr 5: 120.82 – 120.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.

Interactions

DTX1 has been shown to interact with EP300.

Further reading

• Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H (May 2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 (5): 675–85. doi:10.1016/S1074-7613(03)00111-0. PMID 12753744.
• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
• Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A (Mar 2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994.
• Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (Feb 2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231–43. doi:10.1016/S1074-7613(02)00271-6. PMID 11869684.
• Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
• Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (Feb 2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". International Journal of Developmental Neuroscience. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. S2CID 21859491.
• Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID (Dec 2000). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Human Genetics. 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911. S2CID 38695463.
• Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (Jul 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
• Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (Aug 1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. doi:10.1242/dev.121.8.2633. PMID 7671825.
• Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.