Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.[5][6][7] and belongs to thymidylate kinase family of proteins.
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000168393 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026281 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.
- ^ Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.
- ^ "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".
Further reading
edit- Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2–3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
- Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
- Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver". Cancer Res. 40 (4): 1235–9. PMID 6244089.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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