Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene .[ 5] [ 6]
The protein encoded by this gene belongs to the non-receptor class of the protein -tyrosine phosphatase family. The encoded protein has both protein-tyrosine phosphatase activity and serine /threonine -specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000149599 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042662 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff Wingren A, Bremer MC, Holsinger LJ, Millan JL, Mustelin T (Jul 2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX" . J Biol Chem . 279 (31): 32586–91. doi :10.1074/jbc.M403442200 PMID 15138252 . ^ a b "Entrez Gene: DUSP15 dual specificity phosphatase 15" .
Yoon TS, Jeong DG, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase" . Proteins . 61 (3): 694–7. doi :10.1002/prot.20642 PMID 16170801 . S2CID 28160874 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 15
