DUSP22

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.

DUSP22
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WRM, 4WOH
Identifiers
Aliases	DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
External IDs	OMIM: 616778; MGI: 1915926; HomoloGene: 86039; GeneCards: DUSP22; OMA:DUSP22 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p25.3 Start 291,630 bp End 351,355 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.2 Start 30,843,982 bp End 30,895,214 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gingival epithelium hair follicle visceral pleura monocyte gonad parietal pleura Brodmann area 23 tibia endothelial cell Top expressed in lip esophagus spermatid skin of external ear digastric muscle cumulus cell cornea skeletal muscle tissue thoracic diaphragm extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein tyrosine kinase binding Cellular component cytoplasm nucleus cytosol plasma membrane filamentous actin leading edge of lamellipodium Biological process multicellular organism development negative regulation of T cell mediated immunity protein dephosphorylation peptidyl-tyrosine dephosphorylation cell population proliferation negative regulation of T cell activation negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway regulation of cell population proliferation positive regulation of JNK cascade negative regulation of T cell receptor signaling pathway dephosphorylation apoptotic process negative regulation of cell migration negative regulation of focal adhesion assembly cellular response to epidermal growth factor stimulus negative regulation of non-membrane spanning protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56940 105352 Ensembl ENSG00000112679 ENSMUSG00000069255 UniProt Q9NRW4 Q99N11 RefSeq (mRNA) NM_001286555 NM_020185 NM_001037955 NM_134068 RefSeq (protein) NP_001273484 NP_064570 NP_001033044 NP_598829 Location (UCSC) Chr 6: 0.29 – 0.35 Mb Chr 13: 30.84 – 30.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Alonso A, Merlo JJ, Na S, et al. (2002). "Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR)". J. Biol. Chem. 277 (7): 5524–8. doi:10.1074/jbc.M107653200. PMID 11733513.
• Chen AJ, Zhou G, Juan T, et al. (2002). "The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway". J. Biol. Chem. 277 (39): 36592–601. doi:10.1074/jbc.M200453200. PMID 12138158.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Alonso A, Narisawa S, Bogetz J, et al. (2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J. Biol. Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID 15138252.
• Fortna A, Kim Y, MacLaren E, et al. (2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLOS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yokota T, Nara Y, Kashima A, et al. (2007). "Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution". Proteins. 66 (2): 272–8. doi:10.1002/prot.21152. PMID 17068812. S2CID 26785784.
• Sekine Y, Ikeda O, Hayakawa Y, et al. (2007). "DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118". Oncogene. 26 (41): 6038–49. doi:10.1038/sj.onc.1210426. hdl:2115/33065. PMID 17384676.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 22