David Wilkins may refer to:
- David H. Wilkins (born 1946), American politician and ambassador
- David Wilkins (sailor) (born 1950), Irish sailor
- David Wilkins (orientalist) (1685–1745), Prussian orientalist
- David B. Wilkins, American law professor
- David E. Wilkins, Lumbee political scientist and scholar of Native politics
- Dave Wilkins (1914–1990), jazz trumpeter from Barbados