Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase (EC 1.1.1.333, decaprenylphospho-beta-D-ribofuranose 2'-epimerase, Rv3791, DprE2) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.333 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+
The reaction is catalysed in the reverse direction.
References
edit- ^ Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K (January 2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1". Journal of the American Chemical Society. 134 (2): 912–5. doi:10.1021/ja211042r. PMID 22188377.
External links
edit- Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose+2-reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
