Delta11-fatty-acid desaturase (EC 1.14.19.5, Delta11 desaturase, fatty acid Delta11-desaturase, TpDESN, Cro-PG, Delta11 fatty acid desaturase, Z/E11-desaturase, Delta11-palmitoyl-CoA desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta11-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
| Delta11-fatty-acid desaturase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.19.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- acyl-CoA + reduced acceptor + O2 Delta11-acyl-CoA + acceptor + 2 H2O
The enzyme from the marine microalga Thalassiosira pseudonana desaturates palmitic acid 16:0 to 16:1Delta11, whereas that from the leafroller moth Choristoneura rosaceana desaturates myristic acid 14:0 to 14:1Delta11.
References
edit- ^ Tonon T, Harvey D, Qing R, Li Y, Larson TR, Graham IA (April 2004). "Identification of a fatty acid Delta11-desaturase from the microalga Thalassiosira pseudonana". FEBS Letters. 563 (1–3): 28–34. doi:10.1016/S0014-5793(04)00241-8. PMID 15063718. S2CID 83206859.
- ^ Hao G, O'Connor M, Liu W, Roelofs WL (2002). "Characterization of Z/E11- and Z9-desaturases from the obliquebanded leafroller moth, Choristoneura rosaceana". J. Insect Sci. 2:26 (26): 1–7. doi:10.1673/031.002.2601. PMC 355924.
- ^ Rodriguez F, Hallahan DL, Pickett JA, Camps F (1992). "Characterization of the Δ11-palmitoyl-CoA-desaturase from Spodoptera littoralis (Lepidoptera:Noctuidae)". Insect Biochem. Mol. Biol. 22 (2): 143–148. doi:10.1016/0965-1748(92)90152-5.
External links
edit- Delta11-fatty-acid+desaturase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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