Delta6-protoilludene synthase

Δ6-Protoilludene synthase (EC 4.2.3.135, 6-protoilludene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Δ6-protoilludene-forming).[1] This enzyme catalyses the following chemical reaction

Δ6-protoilludene synthase
Identifiers
EC no.4.2.3.135
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
(2E,6E)-farnesyl diphosphate Δ6-protoilludene + diphosphate

This enzyme is isolated from the fungus Armillaria gallica.

References

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  1. ^ Engels B, Heinig U, Grothe T, Stadler M, Jennewein S (2011). "Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides". J. Biol. Chem. 286 (9): 6871–6878. doi:10.1074/jbc.m110.165845. PMC 3044942. PMID 21148562.
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