Delta Kappa Epsilon Fraternity House may refer to:
- Delta Kappa Epsilon Fraternity House (Champaign, Illinois), listed on the U.S. National Register of Historic Places (NRHP)
- Delta Kappa Epsilon Fraternity House (Greencastle, Indiana), listed on the NRHP
- Deke House (Ithaca, New York), listed on the NRHP