The 10/66 Dementia research group was founded in the year 1998 at the Alzheimer's Disease International Annual Conference in Cochin, India. The premise of the research group was that only less than 10% of the population based studies on dementia were being performed in developing countries where about 66% of population with dementia lived. The 10/66 Dementia Research Group aimed to address this imbalance of researches and to encourage collaborations between research centers in various developing nations and between developed nations and developing nations. [1]
Key findings
editDementia epidemiology
editThe prevalence of dementia varied across different settings. It ranged from 4.8% in rural China to 12.6% in Cuba. Such wide variation was attributed to underreporting in less developed settings. In research settings like rural China care givers were less likely to report the social and functional impairment which formed the basis of diagnosis as per DSM - IV.[2] The incidence rate of 10/66 dementia varied between 18.2 per 1000 person-years in Peru to 30.4 per 1000 person-years in Mexico. This was found to be 1.4–2.7 times higher than the incidence reported in DSM-IV dementia. Male sex, higher educational achievement were revealed to be protective factors for dementia. This gave even more supporting evidence for the cognitive reserve hypothesis. [3][4]
Mental health
editEvidence on the prevalence of various Mental health disorders like anxiety and depressive disorders among older adults living in low- and middle-income countries was also very limited. The prevalence of depression was reported to vary from a 0.3% to 13.8%.[5] The prevalence of anxiety was similar to ICD-10 depression estimates. [6]
Non‑communicable diseases
editHypertension was the most common diagnosis (63.6% overall), followed by frailty (15.2%), dementia (8.7%), stroke (7.1%), depression (4.7%) and ischaemic heart disease (4.4%) [7]
References
edit- ^ Prince, Martin J. (January 2009). "The 10/66 dementia research group - 10 years on". Indian Journal of Psychiatry. 51 (Suppl1): S8–S15. ISSN 0019-5545. PMC 3038536. PMID 21416024.
- ^ Rodriguez, Juan J Llibre; Ferri, Cleusa P; Acosta, Daisy; Guerra, Mariella; Huang, Yueqin; Jacob, Ks; Krishnamoorthy, Es; Salas, Aquiles; Sosa, Ana Luisa; Acosta, Isaac; Dewey, Michael E (August 2008). "Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey". The Lancet. 372 (9637): 464–474. doi:10.1016/S0140-6736(08)61002-8. PMC 2854470. PMID 18657855.
- ^ At, Jotheeswaran; Bryce, Renata; Prina, Matthew; Acosta, Daisy; Ferri, Cleusa P; Guerra, Mariella; Huang, Yueqin; Rodriguez, Juan J. Llibre; Salas, Aquiles; Sosa, Ana Luisa; Williams, Joseph D. (December 2015). "Frailty and the prediction of dependence and mortality in low- and middle-income countries: a 10/66 population-based cohort study". BMC Medicine. 13 (1): 138. doi:10.1186/s12916-015-0378-4. ISSN 1741-7015. PMC 4481121. PMID 26063168.
- ^ Prince, Martin; Acosta, Daisy; Ferri, Cleusa P; Guerra, Mariella; Huang, Yueqin; Rodriguez, Juan J Llibre; Salas, Aquiles; Sosa, Ana Luisa; Williams, Joseph D; Dewey, Michael E; Acosta, Isaac (July 2012). "Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study". The Lancet. 380 (9836): 50–58. doi:10.1016/S0140-6736(12)60399-7. PMC 3525981. PMID 22626851.
- ^ Castro-Costa, Erico; Dewey, Michael; Stewart, Robert; Banerjee, Sube; Huppert, Felicia; Mendonca-Lima, Carlos; Bula, Christophe; Reisches, Friedel; Wancata, Johannes; Ritchie, Karen; Tsolaki, Magda (November 2007). "Prevalence of depressive symptoms and syndromes in later life in ten European countries: The SHARE study". British Journal of Psychiatry. 191 (5): 393–401. doi:10.1192/bjp.bp.107.036772. ISSN 0007-1250. PMID 17978318. S2CID 36676042.
- ^ Prina, A. Matthew; Ferri, Cleusa P.; Guerra, Mariella; Brayne, Carol; Prince, Martin (December 2011). "Prevalence of anxiety and its correlates among older adults in Latin America, India and China: cross-cultural study". British Journal of Psychiatry. 199 (6): 485–491. doi:10.1192/bjp.bp.110.083915. ISSN 0007-1250. PMC 3227807. PMID 22016438.
- ^ Sousa, Renata M; Ferri, Cleusa P; Acosta, Daisy; Guerra, Mariella; Huang, Yueqin; Jacob, Ks; Jotheeswaran, At; Hernandez, Milagros A Guerra; Liu, Zhaorui; Pichardo, Guillermina Rodriguez; Rodriguez, Juan J Llibre (December 2010). ""The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey"". BMC Geriatrics. 10 (1): 53. doi:10.1186/1471-2318-10-53. ISSN 1471-2318. PMC 2923155. PMID 20691064.