Demethylrebeccamycin-D-glucose O-methyltransferase (EC 2.1.1.164, RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| Demethylrebeccamycin-D-glucose O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.164 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 4'-demethylrebeccamycin + S-adenosyl-L-methionine rebeccamycin + S-adenosyl-L-homocysteine
Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the Actinobacterium Lechevalieria aerocolonigenes.
References
edit- ^ Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS (May 2006). "RebG- and RebM-catalyzed indolocarbazole diversification". ChemBioChem. 7 (5): 795–804. doi:10.1002/cbic.200500504. PMID 16575939. S2CID 25017820.
- ^ Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN, Thorson JS (August 2008). "Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM". The Journal of Biological Chemistry. 283 (33): 22628–36. doi:10.1074/jbc.M800503200. PMC 2504894. PMID 18502766.
External links
edit- Demethylrebeccamycin-D-glucose+O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
