Derek Johnson may refer to:
- Derek Johnson (athlete) (1933–2004), British track and field athlete
- Derek Johnson (musician) (born 1987), American Christian musician
- Derek Johnson (baseball) (born 1971), American baseball coach
- Derek Wayne Johnson (born 1983), American film director, screenwriter, film producer and actor
- Derek Acorah (Derek Johnson, 1950–2020), self-described spirit medium
- Derek Johnson (politician), MLA in Manitoba