Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine.[1][2][3] It acts as a selective α1-adrenergic receptor agonist.[1][2][3] Desglymidodrine is formed from midodrine via deglycination.[1][2][3]
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| Other names | Deglymidodrine; ST-1059; 3,6-Dimethoxy-β-hydroxy-2-phenylethylamine |
| Drug class | α1-Adrenergic receptor agonist; Antihypotensive agent; Vasopressor |
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| ECHA InfoCard | 100.322.299 |
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| Formula | C10H15NO3 |
| Molar mass | 197.234 g·mol−1 |
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Chemistry
editDesglymidodrine, also known as 3,6-dimethoxy-β-hydroxy-2-phenylethylamine, is a substituted phenethylamine derivative.[4][5]
Midodrine's experimental log P is -0.5 and its predicted log P ranges from -0.49 to -0.95.[6][7] The predicted log P of desglymidodrine ranges from -0.01 to 0.15.[4][5]
An analogue of desglymidodrine is dimetofrine (3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine).
References
edit- ^ a b c McClellan KJ, Wiseman LR, Wilde MI (January 1998). "Midodrine. A review of its therapeutic use in the management of orthostatic hypotension". Drugs & Aging. 12 (1): 76–86. doi:10.2165/00002512-199812010-00007. PMID 9467688.
- ^ a b c Cruz DN (May 2000). "Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension". Expert Opinion on Pharmacotherapy. 1 (4): 835–840. doi:10.1517/14656566.1.4.835. PMID 11249519.
- ^ a b c Gutman LB, Wilson BJ (August 2017). "The Role of Midodrine for Hypotension Outside of the Intensive Care Unit". Journal of Population Therapeutics and Clinical Pharmacology = Journal De La Therapeutique Des Populations Et De La Pharmacologie Clinique. 24 (3): e45–e50. doi:10.22374/1710-6222.24.3.4 (inactive 2024-08-29). PMID 28873293.
{{cite journal}}: CS1 maint: DOI inactive as of August 2024 (link) - ^ a b "Desglymidodrine". PubChem. U.S. National Library of Medicine. Retrieved 1 August 2024.
- ^ a b "Metabolite desglymidodrine". DrugBank Online. Retrieved 1 August 2024.
- ^ "Midodrine". PubChem. U.S. National Library of Medicine. Retrieved 1 August 2024.
- ^ "Midodrine: Uses, Interactions, Mechanism of Action". DrugBank Online. 31 December 1992. Retrieved 1 August 2024.