Destry Rides Again is a 1939 western film starring James Stewart.
Destry Rides Again may also refer to:
- Destry Rides Again (1932 film), starring Tom Mix
- Destry Rides Again (Randy Weston album)
- Destry Rides Again (Roland Hanna album)
- Destry Rides Again (musical), by Harold Rome and Leonard Gershe
- Destry Rides Again (novel), by Max Brand