Di Benedetto (sometimes spelled DiBenedetto) is an Italian surname. Notable people with this name include:
- Alonzo di Benedetto (1664–1729), Italian architect
- Antonio di Benedetto (1922–1986), Argentine writer
- Giacomo Di Benedetto (born 1966), Italian jazz singer
- Giuseppe Di Benedetto (born 1946), Italian heart surgeon
- Ida Di Benedetto (born 1945), Italian actress
- Joseph DiBenedetto, associated with the New York-based Lucchese crime family
- Justin DiBenedetto (born 1988), Canadian hockey player
- Maria Domenica Di Benedetto (born 1953), Italian electrical engineer
- Maria-Gabriella Di Benedetto (born 1958), Italian electrical engineer
- Marco Di Benedetto (born 1995), Italian footballer
- Matt DiBenedetto (born 1991), Italian-American racing driver
- Noemí Di Benedetto (1930–2010), Argentine painter and visual artist
- Pietro di Benedetto dei Franceschi (c. 1415 – 1492), Italian Renaissance painter and mathematician
- Thomas R. DiBenedetto (born 1949), American businessman, chair of AS Roma
- Vincenzo Di Benedetto (1934–2013), Italian philologist
- Zanobi di Benedetto Strozzi (1412–1468), Italian Renaissance painter