Diacylglycerol diphosphate phosphatase (EC 3.1.3.81, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
| Diacylglycerol diphosphate phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.81 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 1,2-diacyl-sn-glycerol 3-diphosphate + H2O 1,2-diacyl-sn-glycerol 3-phosphate + phosphate
The phosphatase activity of this enzyme is Mg2+-independent.
References
edit- ^ Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM (November 1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 271 (48): 30548–53. doi:10.1074/jbc.271.48.30548. PMID 8940025.
- ^ Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM (April 1997). "Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 272 (16): 10361–6. doi:10.1074/jbc.272.16.10361. PMID 9099673.
- ^ Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM (January 1996). "Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae". The Journal of Biological Chemistry. 271 (4): 1868–76. doi:10.1074/jbc.271.4.1868. PMID 8567632.
- ^ Oshiro J, Han GS, Carman GM (November 2003). "Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1635 (1): 1–9. doi:10.1016/j.bbalip.2003.10.002. PMID 14642771.
- ^ Carman GM (September 1997). "Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1348 (1–2): 45–55. doi:10.1016/s0005-2760(97)00095-7. PMID 9370315.
- ^ Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM (March 2001). "Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc". The Journal of Biological Chemistry. 276 (13): 10126–33. doi:10.1074/jbc.m011421200. PMID 11139591.
External links
edit- Diacylglycerol+diphosphate+phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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