Dibrompropamidine is an antiseptic and disinfectant.[1] As dibrompropamidine isethionate, it is used in eyedrops and ointment for the treatment of minor eye and eyelid infections in adults and children. In the UK, such preparations are sold under the brand names Brolene (Aventis Pharma), Golden Eye (Typharm Ltd), and Brulidine (Manx Healthcare).

Dibrompropamidine
Names
Preferred IUPAC name
4,4′-[Propane-1,3-diylbis(oxy)]bis(3-bromobenzene-1-carboximidamide)
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
UNII
  • InChI=1S/C17H18Br2N4O2/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23) checkY
    Key: GMJFVGRUYJHMCO-UHFFFAOYSA-N checkY
  • InChI=1/C17H18Br2N4O2/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23)
    Key: GMJFVGRUYJHMCO-UHFFFAOYAF
  • C1=CC(=C(C=C1C(=N)N)Br)OCCCOC2=C(C=C(C=C2)C(=N)N)Br
  • Brc2cc(ccc2OCCCOc1ccc(C(=[N@H])N)cc1Br)C(=[N@H])N
Properties
C17H18Br2N4O2
Molar mass 470.16 g/mol
Pharmacology
D08AC01 (WHO) S01AX14 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Characteristics

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Dibrompropamidine is a white or almost white crystalline powder. It is odourless or almost odourless. Dibrompropamidine is freely soluble in water, soluble in glycerol, sparingly soluble in ethanol (96%), and practically insoluble in chloroform, in ether, in liquid paraffin and in fixed oils.

References

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  1. ^ PubChem. "Dibrompropamidine". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-11-24.