Diclofenac/misoprostol, sold under the brand name Arthrotec, is a fixed-dose combination medication that contains:
- Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
- Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E1 analog.
| Combination of | |
|---|---|
| Diclofenac | NSAID |
| Misoprostol | Prostaglandin analog |
| Clinical data | |
| Trade names | Arthrotec |
| MedlinePlus | a699002 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
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| (verify) | |
In the United Kingdom it is marketed by Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis or osteoarthritis.[2]
The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.[4]
Contraindications
editArthrotec must not be taken during pregnancy, as it may deform or otherwise harm the fetus, or lead to miscarriage. This may be accompanied by potentially dangerous bleeding, possibly requiring surgery and potentially leading to infertility or death.[2]
References
edit- ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
- ^ a b c "Arthrotec 50 modified-release Tablets - Summary of Product Characteristics (SmPC)". (emc). 17 March 2021. Retrieved 3 August 2021.
- ^ "Arthrotec- diclofenac sodium and misoprostol tablet, film coated". DailyMed. Retrieved 3 August 2021.
- ^ Plosker GL, Lamb HM (July 1999). "Diclofenac/misoprostol. Pharmacoeconomic implications of therapy". PharmacoEconomics. 16 (1): 85–98. doi:10.2165/00019053-199916010-00008. PMID 10539124. S2CID 209146468.
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