Diethyl 2-methyl-3-oxosuccinate reductase

In enzymology, a diethyl 2-methyl-3-oxosuccinate reductase (EC 1.1.1.229) is an enzyme that catalyzes the chemical reaction

diethyl 2-methyl-3-oxosuccinate reductase
Identifiers
EC no.1.1.1.229
CAS no.110369-21-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ diethyl 2-methyl-3-oxosuccinate + NADPH + H+

Thus, the two substrates of this enzyme are diethyl (2R,3R)-2-methyl-3-hydroxysuccinate and NADP+, whereas its 3 products are diethyl 2-methyl-3-oxosuccinate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase.

References

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  • Furuichi A, Akita H, Matsukura H, Oishi T, Horikoshi K (1987). "Purification and properties of an asymmetric reduction of diethyl 2-methyl-3-oxosuccinate in Saccharomyces fermentati". Agric. Biol. Chem. 51 (2): 293–299. doi:10.1271/bbb1961.51.293.