Dihydrocaffeic acid (DHCA; systematic name 3-(3,4-dihydroxyphenyl)propionic acid[1]) is a phytochemical found in grapes and other plants. DHCA is known to lower IL-6 production through down regulation of DNMT1 expression and inhibition of DNA methylation of the IL-6 gene in mice. DHCA in combination with malvidin-3′-O-glucoside (Mal-gluc) is effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation. DHCA/Mal-gluc also significantly lowered depression like phenotypes in mice that had increased peripheral inflammation caused by transplantation of hematopoietic progenitor cells from other more stress-susceptible mice.[2]
Names | |
---|---|
Preferred IUPAC name
3-(3,4-Dihydroxyphenyl)propanoic acid | |
Identifiers | |
3D model (JSmol)
|
|
3DMet | |
2213449 | |
ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.012.804 |
EC Number |
|
482169 | |
KEGG | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C9H10O4 | |
Molar mass | 182.175 g·mol−1 |
Melting point | 136 °C (277 °F; 409 K) |
42.8 g/L | |
Hazards | |
GHS labelling: | |
Warning | |
H315, H319, H335 | |
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
References
edit- ^ PubChem. "3-(3,4-Dihydroxyphenyl)propionic acid". pubchem.ncbi.nlm.nih.gov. Retrieved 2019-12-13.
- ^ Wang, Jun; Hodes, Georgia E.; Zhang, Hongxing; Zhang, Song; Zhao, Wei; Golden, Sam A.; Bi, Weina; Menard, Caroline; Kana, Veronika; Leboeuf, Marylene; Xie, Marc (2018-02-02). "Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice". Nature Communications. 9 (1): 477. doi:10.1038/s41467-017-02794-5. ISSN 2041-1723. PMC 5797143. PMID 29396460. Material was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.