Dishevelled binding antagonist of beta catenin 2

Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene.

DACT2
Identifiers
Aliases	DACT2, C6orf116, DAPPER2, DPR2, bA503C24.7, dishevelled binding antagonist of beta catenin 2
External IDs	OMIM: 608966; MGI: 1920347; HomoloGene: 18237; GeneCards: DACT2; OMA:DACT2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q27 Start 168,292,830 bp End 168,319,777 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A2 Start 14,415,314 bp End 14,424,566 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta testicle putamen nucleus accumbens caudate nucleus apex of heart decidua minor salivary glands skin of leg skin of abdomen Top expressed in renal pelvis midgut umbilical vein renal calyx cervical loop Hindgut visual cortex superior frontal gyrus primary visual cortex primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase C binding beta-catenin binding transcription factor binding protein kinase A binding delta-catenin binding Cellular component cytoplasm Biological process regulation of Wnt signaling pathway hematopoietic progenitor cell differentiation epithelial cell morphogenesis negative regulation of cell adhesion skin development inner medullary collecting duct development negative regulation of nodal signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 168002 240025 Ensembl ENSG00000164488 ENSMUSG00000048826 UniProt Q5SW24 Q7TN08 RefSeq (mRNA) NM_001286350 NM_001286351 NM_214462 NM_172826 RefSeq (protein) NP_001273279 NP_001273280 NP_999627 NP_766414 Location (UCSC) Chr 6: 168.29 – 168.32 Mb Chr 17: 14.42 – 14.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Koga Y, Yao T, Hirahashi M, Kumashiro Y, Ohji Y, Yamada T, Tanaka M, Tsuneyoshi M (2008). "Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence". Histopathology. 52 (5): 569–77. doi:10.1111/j.1365-2559.2008.02996.x. PMID 18370954. S2CID 26122361.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
• Jia Y, Yang Y, Brock MV, Zhan Q, Herman JG, Guo M (2013). "Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer". J. Pathol. 230 (2): 194–204. doi:10.1002/path.4073. PMC 4061565. PMID 22806826.
• Cheng H, Lu M, Mao LJ, Wang JQ, Li W, Wen RM, Chen JC (2012). "Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas". Asian Pac. J. Cancer Prev. 13 (10): 5069–74. doi:10.7314/apjcp.2012.13.10.5069. PMID 23244112.
• Zhang X, Yang Y, Liu X, Herman JG, Brock MV, Licchesi JD, Yue W, Pei X, Guo M (2013). "Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma". Epigenetics. 8 (4): 373–82. doi:10.4161/epi.24113. PMC 3674046. PMID 23449122.
• Gao S, Yang Z, Zheng ZY, Yao J, Zhang F, Wu LM, Xie HY, Zhou L, Zheng SS (2013). "Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing". World J Surg Oncol. 11: 57. doi:10.1186/1477-7819-11-57. PMC 3605395. PMID 23496880.
• Hou J, Liao LD, Xie YM, Zeng FM, Ji X, Chen B, Li LY, Zhu MX, Yang CX, Qing-Zhao, Chen T, Xu XE, Shen J, Guo MZ, Li EM, Xu LY (2013). "DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma". Cancer Prev Res (Phila). 6 (8): 791–800. doi:10.1158/1940-6207.CAPR-12-0352. PMID 23803417.
• Wang S, Dong Y, Zhang Y, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X, Yu J (2015). "DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer". Oncogene. 34 (20): 2575–85. doi:10.1038/onc.2014.201. PMC 4761644. PMID 25023701.