Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) (EC 2.5.1.87, RER2, Rer2p, Rer2p Z-prenyltransferase, Srt1p, Srt2p Z-prenyltransferase, ACPT, dehydrodolichyl diphosphate synthase 1) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10--55 isopentenyl units).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.87 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate n diphosphate + ditrans, polycis-polyprenyl diphosphate (n 10--55)
The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit.
References
edit- ^ Sato M, Fujisaki S, Sato K, Nishimura Y, Nakano A (June 2001). "Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis". Genes to Cells. 6 (6): 495–506. doi:10.1046/j.1365-2443.2001.00438.x. PMID 11442630.
- ^ Poznański J, Szkopinska A (June 2007). "Precise bacterial polyprenol length control fails in Saccharomyces cerevisiae". Biopolymers. 86 (2): 155–64. doi:10.1002/bip.20715. PMID 17345630.
- ^ Sato M, Sato K, Nishikawa S, Hirata A, Kato J, Nakano A (January 1999). "The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis". Molecular and Cellular Biology. 19 (1): 471–83. doi:10.1128/mcb.19.1.471. PMC 83905. PMID 9858571.
- ^ Oh SK, Han KH, Ryu SB, Kang H (June 2000). "Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis". The Journal of Biological Chemistry. 275 (24): 18482–8. doi:10.1074/jbc.M002000200. PMID 10764783.
- ^ Cunillera N, Arró M, Forés O, Manzano D, Ferrer A (July 2000). "Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis". FEBS Letters. 477 (3): 170–4. doi:10.1016/S0014-5793(00)01798-1. PMID 10908715.
External links
edit- Ditrans,polycis-polyprenyl+diphosphate+synthase+((2E,6E)-farnesyl+diphosphate+specific) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
