Donadio or Donadío is a surname. Variations include Donadeo, Donodeo, and Donadei. Notable people with the surname include:
- Candida Donadio (1929-2001), American literary agent
- Giulio Donadio (1889–1951), Italian actor and film director
- Giovanni Francesco Donadio (1449-1530), nicknamed "Mormando", Italian architect and Master organist
- Sebastián Donadío (born 1972), Argentine track cyclist