Donald Mathieson, Donald Matheson, Don Mathieson, or Don Mathesonmay refer to:
- Donald Mathieson (cricketer) (born 1931), Australian cricketer
- Donald Mathieson (businessman), chairman of the Caledonian Railway
- Don Matheson (1929–2014), actor
- Donald Matheson (politician) in 1870 Manitoba general election
- Donald Matheson (missionary) on list of Protestant missionaries in China
- Donald Matheson of Shin, of Clan Matheson
- Donald Macleod Matheson (1896–1979), Secretary to the National Trust
- Donald Matheson, British Army officer, see 1887 Golden Jubilee Honours
- Don Mathieson (lawyer), New Zealand Queens' Council
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