Dorothea Fiedler is a chemical biologist and also the first female director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz Research Institute for Molecular Pharmacology, FMP) in Berlin, Germany.

Dorothea Fiedler
Dorothea Fiedler
Prof. Dr. Dorothea Fiedler
Alma materUniversity of Würzburg (Diplom 2001)
University of California at Berkeley (PhD 2005)
Scientific career
InstitutionsPrinceton University, Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Doctoral advisorsKenneth N. Raymond, Robert G. Bergman
Other academic advisorsKevan M. Shokat

Early life and education

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Fiedler grew up in Hamburg.[1] She studied inorganic chemistry at the University of Würzburg,[2] then carried out doctorate research on organometallic chemistry at the University of California at Berkeley.[1][3]

Research and career

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Although her PhD research focussed on organometallic chemistry[4][5] including host-guest systems and applications to catalysis,[6][7] Fiedler became interested in cellular signal transduction pathways during her postdoctoral research at the University of California, San Francisco.[1][8] She started her independent career as an assistant professor at Princeton University in 2010.[9] Her research focuses on the synthesis and signalling roles of inositol phosphates,[10] in particular, those with a pyrophosphate functionality,[11][12][13][14] which has relevance to cellular signalling and cancer biology.[15][16]

In 2015, Fiedler became the director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie as well as a professor of chemistry at the Humboldt University of Berlin.[17] She continues developing her research focus on the synthesis and signalling roles of protein modifications involving pyrophosphates,[18][19] as well as building collaborations on biological chemistry and catalysis.[20]

Funding, service, and awards

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Fiedler has received a New Innovator Award totalling over $2 million from the NIH in 2013.[21] She also received funding from the Sidney Kimmel Foundation for Cancer Research[22][23] and the Rita Allen Foundation.[24] During her postdoctoral research, she received the Ernst Schering Foundation Postdoctoral Fellowship, was on the Fastrack Program of the Robert Bosch Foundation, and obtained an NIH Pathway to Independence Award.[25]

Fiedler is an invited speaker at the EMBO conference on Chemical Biology 2016[26] and at the International Symposium on Bioorganic Chemistry in 2017.[27]

Fiedler is one of the local organizers of the 42nd National Organic Chemistry Symposium by the organic division of the American Chemical Society in 2011.[28]

References

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  1. ^ a b c "FMP Berlin: Dorothea Fiedler is a new director at the FMP". www.leibniz-fmp.de. 2015-07-14. Retrieved 2019-03-07.[permanent dead link]
  2. ^ "Dorothea Fiedler, Chemie, Humboldt-Universität Berlin". www.uni-wuerzburg.de (in German). Retrieved 2019-03-17.[permanent dead link]
  3. ^ "Dorothea Fiedler | Gesellschaft Deutscher Chemiker e.V." www.gdch.de. Retrieved 2023-08-26.
  4. ^ Fiedler, Dorothea; Pagliero, Daniela; Brumaghim, Julia L.; Bergman, Robert G.; Raymond, Kenneth N. (2004-01-15). "Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage". Inorganic Chemistry. 43 (3): 846–848. doi:10.1021/ic035105s. ISSN 0020-1669. PMID 14753801.
  5. ^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2004-03-06). "Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly". Journal of the American Chemical Society. 126 (12): 3674–3675. doi:10.1021/ja039225a. ISSN 0002-7863. PMID 15038695.
  6. ^ Fiedler, Dorothea; van Halbeek, Herman; Bergman, Robert G.; Raymond, Kenneth N. (2006-07-19). "Supramolecular Catalysis of Unimolecular Rearrangements: Substrate Scope and Mechanistic Insights". Journal of the American Chemical Society. 128 (31): 10240–10252. doi:10.1021/ja062329b. ISSN 0002-7863. PMID 16881654.
  7. ^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2005-04-01). "Selective Molecular Recognition, C−H Bond Activation, and Catalysis in Nanoscale Reaction Vessels". Accounts of Chemical Research. 38 (4): 349–358. CiteSeerX 10.1.1.455.402. doi:10.1021/ar040152p. ISSN 0001-4842. PMID 15835881. S2CID 2954569.
  8. ^ Fiedler, Dorothea; Braberg, Hannes; Mehta, Monika; Chechik, Gal; Cagney, Gerard; Mukherjee, Paromita; Silva, Andrea C.; Shales, Michael; Collins, Sean R. (2009-03-05). "Functional Organization of the S. cerevisiae Phosphorylation Network". Cell. 136 (5): 952–963. doi:10.1016/j.cell.2008.12.039. PMC 2856666. PMID 19269370.
  9. ^ Princeton Alumni Weekly. princeton alumni weekly. 2009-06-10.
  10. ^ "Research - Fiedler Group". www.princeton.edu. Archived from the original on 2015-09-06. Retrieved 2019-03-17.
  11. ^ Campbell, Meghan (2015-02-05). "Lost in Post-Translation :: ChemViews Magazine :: ChemistryViews". www.chemistryviews.org. Retrieved 2019-03-17.
  12. ^ Wu, Mingxuan; Dul, Barbara E.; Trevisan, Alexandra J.; Fiedler, Dorothea (2013). "Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers". Chem. Sci. 4 (1): 405–410. doi:10.1039/C2SC21553E. ISSN 2041-6520. PMC 3558982. PMID 23378892.
  13. ^ Williams, Florence J.; Fiedler, Dorothea (2015-09-18). "A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins". ACS Chemical Biology. 10 (9): 1958–1963. doi:10.1021/acschembio.5b00256. ISSN 1554-8929. PMID 26061479.
  14. ^ Marmelstein, Alan M.; Yates, Lisa M.; Conway, John H.; Fiedler, Dorothea (2014-01-08). "Chemical Pyrophosphorylation of Functionally Diverse Peptides". Journal of the American Chemical Society. 136 (1): 108–111. doi:10.1021/ja411737c. ISSN 0002-7863. PMC 3992712. PMID 24350643.
  15. ^ Shears, Stephen B. (2014-10-05). "Inositol pyrophosphates: Why so many phosphates?". Advances in Biological Regulation. 57: 203–216. doi:10.1016/j.jbior.2014.09.015. PMC 4291286. PMID 25453220.
  16. ^ Shah, Akruti; Ganguli, Shubhra; Sen, Jayraj; Bhandari, Rashna (2017-02-28). "Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules". Journal of the Indian Institute of Science. 97 (1): 23–40. doi:10.1007/s41745-016-0011-3. ISSN 0970-4140. PMC 7081659. PMID 32214696.
  17. ^ "Humboldt-Universität zu Berlin - Dorothea Fiedler". agnes.hu-berlin.de. Retrieved 2019-03-17.
  18. ^ Yates, Lisa M.; Fiedler, Dorothea (2016-04-15). "A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins". ACS Chemical Biology. 11 (4): 1066–1073. doi:10.1021/acschembio.5b00972. ISSN 1554-8929. PMID 26760216.
  19. ^ Marmelstein, Alan M.; Morgan, Jeremy A. M.; Penkert, Martin; Rogerson, Daniel T.; Chin, Jason W.; Krause, Eberhard; Fiedler, Dorothea (2018). "Pyrophosphorylation via selective phosphoprotein derivatization". Chemical Science. 9 (27): 5929–5936. doi:10.1039/C8SC01233D. ISSN 2041-6520. PMC 6050540. PMID 30079207.
  20. ^ "UniSysCat: Signal-controlled multicomponent catalysis". www.unisyscat.tu-berlin.de. Archived from the original on 2021-04-13. Retrieved 2019-03-17.
  21. ^ Fiedler, Dorothea (2013). "Understanding phosphate metabolism in cancer and metastasis". Grantome. Retrieved 2019-03-17.
  22. ^ "The Sidney Kimmel Foundation for Cancer Research Announces 2013 Grant Recipients". PRWeb. Archived from the original on February 22, 2015. Retrieved 2019-03-17.
  23. ^ "Our Scholars". Sidney Kimmel Foundation. Retrieved 2019-03-17.
  24. ^ "Years 2013 - Rita Allen Foundation". Retrieved 2019-03-17.
  25. ^ "UniSysCat: Fiedler, Dorothea". www.unisyscat.tu-berlin.de. Archived from the original on 2021-04-13. Retrieved 2019-03-17.
  26. ^ "EMBO Conference - Chemical Biology 2016 - Speakers". www.embl.de. Retrieved 2019-03-17.
  27. ^ "Speakers | Programme | International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology | University of Konstanz". www.uni-konstanz.de. Retrieved 2019-03-17.[permanent dead link]
  28. ^ "- NOS History". ACS Division of Organic Chemistry. 4 November 2016. Retrieved 2019-03-17.