Downshire may refer to the following:
- Antarctica
- Northern Ireland
- County Down
- Downshire Hospital, psychiatric hospital at Downpatrick, County Down
- Downshire School, Carrickfergus, County Antrim
- Downshire railway station, Carrickfergus, County Antrim
- Downshire Young Men F.C., Hillsborough, County Down
- Downshire, electoral area of Lisburn City Council
- Marquess of Downshire
- England
- Downshire Hill, street in Hampstead, London