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Comment: Can you find and add sources to add to Education? because that segment has no sources. RangersRus (talk) 00:49, 4 December 2024 (UTC)
Bethan Psaila | |
|---|---|
| Alma mater | University of Cambridge
Imperial College London Weill Cornell Medical College |
| Website | https://www.rdm.ox.ac.uk/people/bethan-psaila |
Bethan Psaila is a physician-scientist known for work in hematopoietic stem cell biology in myeloproliferative neoplasms (MPNs). She is an Associate Professor of Hematology at the University of Oxford, a Cancer Research UK funded Senior Fellow, and a Senior Fellow of New College.
Education
editPsaila received her undergraduate and medical training at Clare College, Cambridge and University College London Hospitals. She went on to pursue a PhD at Imperial College London and Weill-Cornell University Medical School in New York, where she studied the role of megakaryocytes in cancer metastasis. She completed her specialty training in hematology at the Hammersmith Hospital as an NIHR Academic Clinical Lecturer at Imperial College London. Psaila was granted a prestigious Wellcome Career Development Fellowship, which supported further postdoctoral research in David Bodine's laborotary at the National Human Genome Research Institute in Maryland and with Professors Adam Mead and Irene Roberts at the MRC Weatherall Institute of Molecular Medicine, University of Oxford.[citation needed]
Research
editDr. Psaila is an Associate Professor of Hematology at the University of Oxford and serves as a Group Leader at the MRC Weatherall Institute of Molecular Medicine and the Oxford Ludwig Institute for Cancer Research.[1]. Her research focuses on the tumor microenvironment in blood cancers[2]:
- Interactions in normal and malignant hematopoiesis: Investigating the interactions between blood stem cells, megakaryocytes, and the stroma in both normal and malignant hematopoiesis.
- Bone Marrow Organoids: Development and application of human bone marrow organoids to study hematopoiesis and validate therapeutic targets in the relevant tissue microenvironment.
- Selective targeting: Developing novel strategies to selectively target disease-driving cancer stem cells and pathological megakaryocytes in myelofibrosis, a severe bone marrow malignancy.
- Platelet biology and early detection: Exploring the utility of platelet-associated DNA fragments in cancer detection and pre-natal diagnosis.
Honors and awards
editIn 2015, Psaila was awarded a Wellcome Career Development Fellowship to use single cell techniques to study molecular mechanisms of abnormal megkaryocyte development in myelofibrosis[3].
In 2017, Psaila won a prestigious Fellowship at the L’Oréal-UNESCO UK and Ireland For Women In Science[4][5]
In 2021, Psaila received the RDM-WIMM Sir Andrew McMichael Award for Excellent Supervision and Mentorship, recognizing her exceptional mentorship and support of trainees.
In 2024, Psaila was awarded a Senior Fellowship funded by Cancer Research UK in partnership with the Rosetrees Trust[6][7]. This fellowship supports her research into the progression of cancers from indolent to advanced stages and the development of new therapies.
Selected publications
edit- Li, R., Colombo, M., Wang, G., Rodriguez-Romera, A., Benlabiod, C., Jooss, N. J., ... & Psaila, B. (2024). A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis. Science translational medicine, 16(768), eadj7552.[8]
- Olijnik, A. A., Rodriguez-Romera, A., Wong, Z. C., Shen, Y., Reyat, J. S., Jooss, N. J., ... & Psaila, B., Khan, A. O. (2024). Generating human bone marrow organoids for disease modeling and drug discovery. Nature Protocols, 1-30.[9]
- Khan, A. O., Rodriguez-Romera, A., Reyat, J. S., Olijnik, A. A., Colombo, M., Wang, G., ... & Psaila, B. (2023). Human bone marrow organoids for disease modeling, discovery, and validation of therapeutic targets in hematologic malignancies. Cancer discovery, 13(2), 364-385.[10]
- Psaila, B., Wang, G., Rodriguez-Meira, A., Li, R., Heuston, E. F., Murphy, L., ... & Mead, A. J. (2020). Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets. Molecular cell, 78(3), 477-492.[11]
References
edit- ^ "Bethan Psaila". www.rdm.ox.ac.uk. Retrieved 2024-12-03.
- ^ "Psaila Group: The tumour microenvironment in blood cancers". www.rdm.ox.ac.uk. Retrieved 2024-12-03.
- ^ "Wellcome Trust Postdoctoral Fellowship Awarded". www.imm.ox.ac.uk. Retrieved 2024-12-03.
- ^ "Dr Beth Psaila wins L'Oréal-UNESCO Women in Science Award". www.imm.ox.ac.uk. Retrieved 2024-12-03.
- ^ researchfeatures (2018-03-06). "Women in Science: L'Oréal and UNESCO partnership supports female scientists". Research Features. Retrieved 2024-12-03.
- ^ "Senior Fellowship awarded to Beth Psaila". www.rdm.ox.ac.uk. Retrieved 2024-12-03.
- ^ Inc, P53 (2024-08-29). "Beth Psaila: Thrilled to receive a Senior Science and Innovation at Cancer Research UK Fellowship - OncoDaily". oncodaily.com. Retrieved 2024-12-03.
{{cite web}}:|last=has generic name (help)CS1 maint: numeric names: authors list (link) - ^ Li, Rong; Colombo, Michela; Wang, Guanlin; Rodriguez-Romera, Antonio; Benlabiod, Camelia; Jooss, Natalie J.; O’Sullivan, Jennifer; Brierley, Charlotte K.; Clark, Sally-Ann; Pérez Sáez, Juan M.; Fernández, Pedro Aragón; Schoof, Erwin M.; Porse, Bo; Meng, Yiran; Khan, Abdullah O. (2024-10-09). "A proinflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis". Science Translational Medicine. 16 (768): eadj7552. doi:10.1126/scitranslmed.adj7552. ISSN 1946-6234. PMC 7616771. PMID 39383242.
- ^ Olijnik, Aude-Anais; Rodriguez-Romera, Antonio; Wong, Zoë C.; Shen, Yuqi; Reyat, Jasmeet S.; Jooss, Natalie J.; Rayes, Julie; Psaila, Bethan; Khan, Abdullah O. (July 2024). "Generating human bone marrow organoids for disease modeling and drug discovery". Nature Protocols. 19 (7): 2117–2146. doi:10.1038/s41596-024-00971-7. ISSN 1750-2799.
- ^ Khan, Abdullah O.; Rodriguez-Romera, Antonio; Reyat, Jasmeet S.; Olijnik, Aude-Anais; Colombo, Michela; Wang, Guanlin; Wen, Wei Xiong; Sousos, Nikolaos; Murphy, Lauren C.; Grygielska, Beata; Perrella, Gina; Mahony, Christopher B.; Ling, Rebecca E.; Elliott, Natalina E.; Karali, Christina Simoglou (2023-02-06). "Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies". Cancer Discovery. 13 (2): 364–385. doi:10.1158/2159-8290.CD-22-0199. ISSN 2159-8274. PMC 9900323. PMID 36351055.
- ^ Psaila, Bethan; Wang, Guanlin; Rodriguez-Meira, Alba; Li, Rong; Heuston, Elisabeth F.; Murphy, Lauren; Yee, Daniel; Hitchcock, Ian S.; Sousos, Nikolaos; O’Sullivan, Jennifer; Anderson, Stacie; Senis, Yotis A.; Weinberg, Olga K.; Calicchio, Monica L.; Iskander, Deena (2020-05-07). "Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets". Molecular Cell. 78 (3): 477–492.e8. doi:10.1016/j.molcel.2020.04.008. ISSN 1097-2765. PMC 7217381. PMID 32386542.